Formula: C8H10N4O2
Molar mass: 194.19 g/mol
IUPAC ID: 1,3,7-Trimethylpurine-2,6-dione
Metabolism: Primary: CYP1A2; Minor: CYP2E1, CYP3A4, CYP2C8, CYP2C9
Pronunciation: /kæˈfiːn, ˈkæfiːn/
Other names: Guaranine; Methyltheobromine; 1,3,7-Trimethylxanthine; 7-methyltheophylline Theine
Protein binding: 25–36%

Caffeine (카페인 / คาเฟอีน)

Caffeine is a central nervous system stimulant of the methylxanthine class. It is mainly used recreationally or as a cognitive enhancer, increasing alertness and attentional performance. Wikipedia

Some of the signs and symptoms of having too much caffeine include:

• a rise in body temperature
• frequent urination
• dehydration
• dizziness and headaches
• rapid heartbeat (palpitations)
• restlessness and excitability
• anxiety and irritability
• trembling hands

Details: 

The etymology is simply the addition of ‘Coffe-‘ in ‘ coffee ‘ with ‘-ine’ meaning an alkaloid (amine) substance. It is also called coffee in coffee as a joke. 1819 German scientist Friedliff Ferdinand RungeIt was first discovered by extracting from coffee beans by. Runge’s discovery of caffeine was greatly influenced by Goethe, a great German writer and close friend of Runge. In 1819, Runge, who was 25 years old at the time, discovered a plant called ‘Belladonna’ that had a muscle-relaxing effect on the pupils of cats (…). Extract of After was dropped, the pupil dilated experiment was demonstrated. Impressed by this (?), Goethe gave him Arabian Mocha coffee beans as a gift and asked, ‘Why does coffee wake people up by analyzing the ingredients in it? It is said that he said, ‘Please let me know if there is.

Runge called this ingredient simply Kaffebase, which means the active ingredient of coffee. Pierre Joseph Pelletier and Joseph Bienaimé Caventou published a thesis and caféine. The name  was widely settled and became hardened here. However, Peltier later admitted and published that Runge had discovered caffeine a step ahead of him. #

For medicinal purposes, caffeine extracted from the decaffeinated coffee manufacturing process is often used. It is a by-product of crops that are in high demand, and there are also crops that specialize in caffeine production, such as guarana.

Coffee isn’t the only plant that has caffeine. It is also present in cacao, kola, guarana, tea, and mate.

Characteristics and Side Effects

First of all, of course, there is an awakening effect. You just need to know that being awake is not very good. Caffeine’s awakening effect itself excites the central nervous system, constricts blood vessels, raises blood pressure, and secretes stress hormones such as adrenaline and glucocorticoids. It literally wakes up the brain so that you don’t feel fatigued, not to restore fatigue itself. Caffeine helps you concentrate, so if you experience brain fog due to ‘sleep debt’, you should get enough sleep.

The most common side effects of caffeine overdose are heartburn and indigestion. Caffeine irritates the gastrointestinal mucosa. Therefore, it promotes the secretion of gastric acid and causes heartburn and, in severe cases, gastritis and esophagitis .symptoms appear. It also promotes the secretion of adrenaline, which contributes to mental anxiety. Therefore, among those who enjoy drinking caffeinated beverages such as coffee and energy drinks, there are quite a few people who feel unwell or have nervousness.

The same is true of nicotine and central nervous system stimulants. Various media claim that caffeine does not strain the body, but that is tea and food companies and cartels, and it is absurd to say that there are no side effects at all in a situation where research results on caffeine and side effects are pouring out. Of course, it is much safer than alcohol or cigarettes.

Sensitivity to caffeine varies considerably from person to person. The ability of enzymes to decompose caffeine is genetic, so some people are sensitive to even one cup of coffee, while others sleep well even after three or four cups. Although it is rare, some people are naturally strong against caffeine to the extent that they cannot even hear Monster Energy. If you do not feel the awakening effect even after taking an energy drink, it is wise not to overdose and try to avoid drowsiness in other ways.

On the other hand, some sensitive people say that they cannot sleep even if they eat not only coffee, but also green tea, chocolate, and cola. And, with some people having different sensitivity to caffeine over time, it’s literally kebab. The CYP1A2 gene determines the rate of caffeine metabolism for each individual. This gene regulates an enzyme that breaks down caffeine. There are two types, 1A and 1F. People with the 1A allele have a fast metabolism, making it difficult to feel the effects of caffeine. In the case of 1F, on the contrary, it is not decomposed well, so the effect of caffeine lasts for a long time. If you have ADHD, it is better to refrain from stimulants such as caffeine when taking DNRI drugs.